Covid-Miner bioinformatics workflow

interactive SARS-CoV-2 variant browsing portal

The COVID-Miner is a bioinformatics framework that enables to the extraction of single mutations, Pangolin lineages, and consensus from GISAID SARS-CoV-2 sequences. This interactive Data Portal stands as a user-friendly interface to browse the most prominent lineages and Receptor Binding Domain (RBD) Spike mutations worldwide. The choice of RBD variants stems from the scientific evidence that immune response escape from vaccines and neutralizing antibodies mostly lies in this section of the SARS-CoV-2 genome.
The result of this work has been published on Journal of Translational Medicine (Massacci A. 2020)

Design of a Companion Bioinformatic Tool to detect the emergence and geographical distribution of SARS-CoV-2 Spike protein genetic variants

Alice Massacci, Eleonora Sperandio, Lorenzo D'Ambrosio, Mariano Maffei, Fabio Palombo, Luigi Aurisicchio, Gennaro Ciliberto, Matteo Pallocca

This analysis has been carried out by a team of bioinformaticians from

Istituti Fisioterapici Ospitalieri - Istituto Dermatologico San Gallicano and Istituto Nazionale Tumori Regina Elena logos
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